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  • Modeling Fragile X Syndrome

    Edición de Robert B. Denman ...
    Series series Biomedical and Life Sciences (R0)
    Introduction.-Probing Astrocyte Function in Fragile X Syndrome.- Neural Stem Cells.- Fragile X Mental Retardation Protein (FMRP) and the Spinal Sensory System.– The Role of the Postsynaptic Density in the Pathology of the Fragile X Syndrome.- Behavior in a Drosophila model of Fragile X.- Molecular and Genetic Analysis of the Drosophila Model of Fragile X Syndrome.- Fragile X Mental Retardation ... Leer más

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  • Semaphorins

    A Diversity of Emerging Physiological and Pathological Activities

    Edición de Atsushi Kumanogoh ...
    Series series Biomedical and Life Sciences (R0)
    This book presents the current concepts of semaphorin biology. In the early 1990s, semaphorins were originally identified as axon guidance cues that function during neuronal development. However, cumulative findings have clarified that they have diverse functions in many physiological processes, including cardiogenesis, angiogenesis, vasculogenesis, osteoclastogenesis, retinal homeostasis, and ... Leer más

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  • Trinucleotide Diseases and Instability

    Edición de Ben A. Oostra ...
    Series series Biomedical and Life Sciences (R0)
    Till recently, mutations in genes were described in textbooks as deletions or point mutations. These mutations can be inherited from a parent or they are de novo alterations. The discovery in 1991 that human disease can be caused by large-scale ex pansion of highly unstable trinucleotide repeats has elucidated a new mutation mechanism, heritable unstable DNA. In the subsequent years more then 10 ... Leer más

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  • Folding for the Synapse

    Series series Biomedical and Life Sciences (R0)
    Folding for the Synapse addresses the current view on how protein folding and misfolding, controlled by molecular chaperones, contribute to synapse function and dysfunction. Molecular chaperones have been studied in relation to de novo protein folding, but there is increasing awareness that chaperone function is required for the regulation of protein dynamics when functioning physiologically as an ... Leer más

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  • Stem Cells and Cancer Stem Cells, Volume 7

    Therapeutic Applications in Disease and Injury

    Edición de M.A. Hayat ...
    Series series Biomedical and Life Sciences (R0)
    The seventh in Springer’s landmark series of edited volumes on one of the highest-profile subjects in contemporary medicine and scientific endeavour, this volume sets out to cover a staggering range of research into the medical applications of stem cell research. While stem cells are the very stuff of life for multicellular organisms, including us humans, the cancer stem cell is a morbid entity ... Leer más

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  • Perspectives of Stem Cells

    From tools for studying mechanisms of neuronal differentiation towards therapy

    Edición de Henning Ulrich ...
    Series series Biomedical and Life Sciences (R0)
    Stem cells are fascinating cell types. They can replicate themselves forever while retaining the potential to generate progeny with speci?c functions. Because of these special properties, stem cells have been subjects of intensive investigation, from understanding basic mechanisms underlying tissue generation, to modeling human diseases, to application for cell replacement therapy. Stem cells come ... Leer más

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  • Perspectives in Translational Research in Life Sciences and Biomedicine

    Translational Outcomes Research in Life Sciences and Translational Medicine, Volume 1

    Series series Biomedical and Life Sciences (R0)
    The present book addresses the multi-disciplinary nature of Translational Outcomes Research, which is a watershed for nearly all the disciplines of Life and Health Sciences, along with the Materials Sciences including but not limited to Zoology, Botany, Microbiology, Biochemistry, Physiology, Nanotechnology, the Medical Sciences, Bioengineering, Biophysics, Medicinal Chemistry, Structural Biology, ... Leer más

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  • The Neural Crest and Neural Crest Cells in Vertebrate Development and Evolution

    de Brian K. Hall ...
    Series series Biomedical and Life Sciences (R0)
    A presentation of all aspects of neural crest cell origins (embryological and evolutionary) development and evolution; neural crest cell behavior (migration) and anomalies (neurocristopathies and birth defects) that arise from defective neural crest development. The treatment of development will include discussions of cellular, molecular and genetic aspects of the differentiation and morphogenesis ... Leer más

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  • Molecularly Targeted Therapy for Childhood Cancer

    Series series Biomedical and Life Sciences (R0)
    Each chapter will focus on the known molecular characteristics of specific childhood cancers, focusing on how the molecular ‘drivers’ can be exploited from a therapeutic standpoint with currently available targeted agents. Where applicable, integration of targeted therapies with conventional cytotoxic agents will be considered.This volume will provide a comprehensive summary of molecular ... Leer más

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  • Epigenetics and Dermatology

    Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages of life (from a fetus in ... Leer más

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  • Behavioral Neurogenetics

    Edición de John F. Cryan, Andreas Reif ...
    Series series Biomedical and Life Sciences (R0)
    This book covers a wide array of topics relevant to behavioral genetics from both a preclinical and clinical standpoint. Indeed in juxtaposing both areas of research the reader will appreciate the true translational nature of the field. Topics covered range from technical advances in genetic analysis in humans and animals to specific descriptions of advances in schizophrenia, attention disorders, ... Leer más

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