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Attrition in the Pharmaceutical Industry

Reasons, Implications, and Pathways Forward

de Alexander Alex, C. John Harris, Dennis A. Smith ...

With a focus on case studies of R&D programs in a variety of disease areas, the book highlights fundamental productivity issues the pharmaceutical industry has been facing and explores potential ways of improving research effectiveness and efficiency.Takes a comprehensive and holistic approach to the problems and potential solutions to drug compound attritionTackles a problem that adds billions of ... Leer más

$126.00 USD

With a focus on case studies of R&D programs in a variety of disease areas, the book highlights fundamental productivity issues the pharmaceutical industry has been facing and explores potential ways of improving research effectiveness and efficiency.Takes a comprehensive and holistic approach to the problems and potential solutions to drug compound attritionTackles a problem that adds billions of
... Leer más

Pharmaceutical Lifecycle Management

Making the Most of Each and Every Brand

de Tony Ellery, Neal Hansen ...

A comprehensive guide to optimizing the lifecycle management of pharmaceutical brandsThe mounting challenges posed by cost containment policies and the prevalence of generic alternatives make optimizing the lifecycle management (LCM) of brand drugs essential for pharmaceutical companies looking to maximize the value of their products. Demonstrating how different measures can be combined to create ... Leer más

$88.00 USD

A comprehensive guide to optimizing the lifecycle management of pharmaceutical brandsThe mounting challenges posed by cost containment policies and the prevalence of generic alternatives make optimizing the lifecycle management (LCM) of brand drugs essential for pharmaceutical companies looking to maximize the value of their products. Demonstrating how different measures can be combined to create
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Drug Discovery Toxicology

From Target Assessment to Translational Biomarkers

Edición de J. Eric McDuffie, Andrew J. Olaharski, Brandon D. Jeffy, Yvonne Will ...

As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process.• Guides researchers as to what drug safety experiments are both practical and useful• Covers a variety of key topics – safety lead optimization, in vitro-in vivo ... Leer más

$181.00 USD

As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process.• Guides researchers as to what drug safety experiments are both practical and useful• Covers a variety of key topics – safety lead optimization, in vitro-in vivo
... Leer más
Cardiovascular Diseases

From Molecular Pharmacology to Evidence-Based Therapeutics

de Y. Robert Li ...

Written in an accessible style and consistent format, the book covers both the fundamentals and advances in the pharmacology of cardiovascular drugs, as well as their integrated applications in the management of individual cardiovascular diseases.• Integrates fundamentals and recent advances regarding cardiovascular drugs, blending basic and clinical sciences needed to effectively understand and ... Leer más

$123.00 USD

Written in an accessible style and consistent format, the book covers both the fundamentals and advances in the pharmacology of cardiovascular drugs, as well as their integrated applications in the management of individual cardiovascular diseases.• Integrates fundamentals and recent advances regarding cardiovascular drugs, blending basic and clinical sciences needed to effectively understand and
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ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins

Applications in Drug Discovery and Development

de Honghui Zhou, Frank-Peter Theil ...

With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs.Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugsCombines theoretical with practical aspects of ADME in ... Leer más

$133.00 USD

With an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs.Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugsCombines theoretical with practical aspects of ADME in
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High-Throughput Screening Methods in Toxicity Testing

Edición de Pablo Steinberg ...

Explores the benefits and limitations of the latest high-throughput screening methodsWith its expert coverage of high-throughput in vitro screening methods for toxicity testing, this book makes it possible for researchers to accelerate and streamline the evaluation and risk assessment of chemicals and drugs for toxicity. Moreover, it enables them to comply with the latest standards set forth by ... Leer más

$152.00 USD

Explores the benefits and limitations of the latest high-throughput screening methodsWith its expert coverage of high-throughput in vitro screening methods for toxicity testing, this book makes it possible for researchers to accelerate and streamline the evaluation and risk assessment of chemicals and drugs for toxicity. Moreover, it enables them to comply with the latest standards set forth by
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Metabolite Safety in Drug Development

Edición de Suzanne L. Iverson, Dennis A. Smith ...

A reference on drug metabolism and metabolite safety in the development phase, this book reviews the analytical techniques and experimental designs critical for metabolite studies. It features case studies of lessons learned and real world examples, along with regulatory perspectives from the US FDA and EMA.• Reviews the analytical techniques and experimental designs critical for metabolite ... Leer más

$181.00 USD

A reference on drug metabolism and metabolite safety in the development phase, this book reviews the analytical techniques and experimental designs critical for metabolite studies. It features case studies of lessons learned and real world examples, along with regulatory perspectives from the US FDA and EMA.• Reviews the analytical techniques and experimental designs critical for metabolite
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Oral Formulation Roadmap from Early Drug Discovery to Development

Edición de Elizabeth Kwong ...

Detailing formulation approaches by stage of discovery to early development, this book gives a “playbook” of practical and efficient strategies to formulate drug candidates with the least chance of failing in clinical development.• Comes from contributing authors with experience developing formulations on the frontlines of the pharmaceutical industry• Focuses on pre (or non-) clinical and early ... Leer más

$138.00 USD

Detailing formulation approaches by stage of discovery to early development, this book gives a “playbook” of practical and efficient strategies to formulate drug candidates with the least chance of failing in clinical development.• Comes from contributing authors with experience developing formulations on the frontlines of the pharmaceutical industry• Focuses on pre (or non-) clinical and early
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Oral Bioavailability Assessment

Basics and Strategies for Drug Discovery and Development

de Ayman F. El-Kattan, Mike S. Lee ...

Series series Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods
Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development.• Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability• Helps readers reduce the failure rate of drug ... Leer más

$155.00 USD

Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development.• Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability• Helps readers reduce the failure rate of drug
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Antibody-Drug Conjugates

Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer

Edición de Kenneth J. Olivier Jr., Sara A. Hurvitz ...

Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells.• Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies• Covers the conduct and design of oncology clinical trials and ... Leer más

$138.00 USD

Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells.• Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies• Covers the conduct and design of oncology clinical trials and
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From Artemisia annua L. to Artemisinins

The Discovery and Development of Artemisinins and Antimalarial Agents

de Youyou Tu ...

From Artemisia annua L. to Artemisinins: The Discovery and Development of Artemisinins and Antimalarial Agents is the first book that systematically introduces the origin and development of artemisinine and artemisinine-based drugs. It includes four distinct sections, including Artemisia annua L., Artemisinin, Dihydroartemisinin, and other artemisinin derivatives. Tu Youyou, the chief inventor of ... Leer más

$134.99 USD

From Artemisia annua L. to Artemisinins: The Discovery and Development of Artemisinins and Antimalarial Agents is the first book that systematically introduces the origin and development of artemisinine and artemisinine-based drugs. It includes four distinct sections, including Artemisia annua L., Artemisinin, Dihydroartemisinin, and other artemisinin derivatives. Tu Youyou, the chief inventor of
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Polypharmacology in Drug Discovery

Edición de Jens-Uwe Peters ...

An essential outline of the main facets of polypharmacology in drug discovery researchExtending drug discovery opportunities beyond the "one drug, one target" philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in both industry and academic research. Polypharmacology in Drug Discovery presents an overview of the various facets of ... Leer más

$127.00 USD

An essential outline of the main facets of polypharmacology in drug discovery researchExtending drug discovery opportunities beyond the "one drug, one target" philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in both industry and academic research. Polypharmacology in Drug Discovery presents an overview of the various facets of
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Attrition in the Pharmaceutical Industry

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Pharmaceutical Lifecycle Management

Drug Discovery Toxicology

Cardiovascular Diseases

ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins

High-Throughput Screening Methods in Toxicity Testing

Metabolite Safety in Drug Development

Oral Formulation Roadmap from Early Drug Discovery to Development

Oral Bioavailability Assessment

Antibody-Drug Conjugates

From Artemisia annua L. to Artemisinins

Polypharmacology in Drug Discovery

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