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“helmut greim”

Showing 1 - 12 of 12 results for “helmut greim”
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  • Toxicology and Risk Assessment

    A Comprehensive Introduction

    Edited by Helmut Greim, Robert Snyder ...
    Provides a complete understanding of how our bodies respond to toxicants, and the principles used to assess the health risks of specific exposure scenariosToxicology and Risk Assessment: A Comprehensive Introduction, Second Edition reflects recent advances in science and technology, and provides the scientific background and methodological issues to enable the reader to understand the basic ... Read more

    $142.00 USD

  • Cellular Response to the Genotoxic Insult

    The Question of Threshold for Genotoxic Carcinogens

    Edited by Helmut Greim, Richard Albertini ...
    Series series
    Genotoxic carcinogens can lead to DNA mutations with the potential to cause cancer. Typically, a series of mutation events are needed before malignancy occurs so a single, small exposure may not result in disease. Also, cells have an armoury of defence mechanisms which, to a degree, counter the effects of mutagens. Distinguishing the point at which exposure to a carcinogen increases mutation rates ... Read more

    $214.19 USD

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  • DNA Repair in Cancer Therapy

    Molecular Targets and Clinical Applications

    Edited by Mark R. Kelley ...
    Cancer therapeutics include an ever-increasing array of tools at the disposal of clinicians in their treatment of this disease. However, cancer is a tough opponent in this battle, and current treatments, which typically include radiotherapy, chemotherapy and surgery, are not often enough to rid the patient of his or her cancer. Cancer cells can become resistant to the treatments directed at them, ... Read more

    $123.29 USD

  • HIV-1 Integrase

    Mechanism and Inhibitor Design

    by Binghe Wang ...
    Series Book 9 - Wiley Series in Drug Discovery and Development
    This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging drug design issues and researchers in antiviral drug discovery. Despite numerous review articles and isolated book chapters dealing with HIV-1 integrase, there has not been a single source for those working to devise anti-AIDS drugs against ... Read more

    $158.00 USD

  • DNA Repair in Cancer Therapy

    Molecular Targets and Clinical Applications

    Edited by Mark R. Kelley, Melissa L. Fishel ...
    DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment. Experts on DNA repair proteins from all areas of cancer biology research take readers from ... Read more

    $143.99 USD

  • RNA Interference

    Application to Drug Discovery and Challenges to Pharmaceutical Development

    Edited by Paul H. Johnson ...
    RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development provides a general overview of this rapidly emerging field, with a strong emphasis on issues and aspects that are important to a drug development team. The first part covers more general background of RNA interference and its application in drug discovery. In the second part, the book addresses siRNA ... Read more

    $129.00 USD

  • Medicinal Chemistry of Anticancer Drugs

    by Carmen Avendaño, J. Carlos Menéndez ...
    Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research ... Read more

    $179.99 USD

  • Lentiviral Vectors and Gene Therapy

    by David Escors, Karine Breckpot, Frederick Arce, Grazyna Kochan, Holly Stephenson ...
    Series series Biomedical and Life Sciences (R0)
    Gene therapy was conceived during the early and mid part of the 20th century. At first, it was considered a revolutionary biomedical procedure, which could potentially cure any disease for which the molecular bases were understood. Since then, gene therapy has gone through many stages and has evolved from a nearly unrealistic perspective to a real life application. Clinical efficacy in humans was ... Read more

    $49.49 USD

  • Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

    Edited by M. A. Hayat ...
    Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series ... Read more

    $179.99 USD

  • Mitochondria and Cancer

    Edited by Keshav Singh, Leslie Costello ...
    Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration ... Read more

    $134.09 USD

  • Anticancer Genes

    Edited by Stefan Grimm ...
    Series series Biomedical and Life Sciences (R0)
    This book discusses the emergence of a new class of genes with a specific anticancer activity. These genes, recently defined as “Anticancer Genes”, are reviewed in individual chapters on their mode of action, the specific cell death signals they induce, and the status of attempts to translate them into clinical application.Anticancer Genes provides an overview of this nascent field, its genesis, ... Read more

    $89.09 USD

  • Mitochondrial DNA, Mitochondria, Disease and Stem Cells

    Edited by Justin C. St. John ...
    Series series Biomedical and Life Sciences (R0)
    This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring’s well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and ... Read more

    $98.09 USD