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Showing 1 - 12 of 22 results for “gerd folkers”
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  • Transporters as Drug Targets

    by Raimund Mannhold, Gerd Folkers, Helmut Buschmann ...
    Series series Methods & Principles in Medicinal Chemistry
    As opposed to other books on the topic, this volume is unique in also covering emerging transporter targets.Following a general introduction to the importance of targeting transporter proteins with drugs, the book systematically presents individual transporter classes and explains their pharmacology and physiology. The text covers all transporter families with known or suspected importance as drug ... Read more

    $151.00 USD

  • Protein Therapeutics

    by Raimund Mannhold, Gerd Folkers, Helmut Buschmann ...
    Series series Methods & Principles in Medicinal Chemistry
    In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and drug developers of all trades.Following an introduction tracing the rapid development of the protein therapeutics market over the last decade, ... Read more

    $282.00 USD

  • Lead Generation

    Methods and Strategies

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series series Methods & Principles in Medicinal Chemistry
    In this comprehensive two-volume resource on the topic senior lead generation medicinal chemists present a coherent view of the current methods and strategies in industrial and academic lead generation. This is the first book to combine both standard and innovative approaches in comparable breadth and depth, including several recent successful lead generation case studies published here for the ... Read more

    $275.00 USD

  • Fragment-based Drug Discovery

    Lessons and Outlook

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series series Methods & Principles in Medicinal Chemistry
    From its origins as a niche technique more than 15 years ago, fragment-based approaches have become a major tool for drug and ligand discovery, often yielding results where other methods have failed. Written by the pioneers in the field, this book provides a comprehensive overview of current methods and applications of fragment-based discovery, as well as an outlook on where the field is headed ... Read more

    $151.00 USD

  • Animal Models for Human Cancer

    Discovery and Development of Novel Therapeutics

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series series Methods & Principles in Medicinal Chemistry
    Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results.Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the book describes correct study design as well as the ... Read more

    $129.00 USD

  • Thermodynamics and Kinetics of Drug Binding

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series series Methods & Principles in Medicinal Chemistry
    This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects.Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and ... Read more

    $151.00 USD

  • Reactive Drug Metabolites

    by Deepak Dalvie, R. Scott Obach, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers, Dennis A. Smith, Amit S. Kalgutkar ...
    Series Book 55 - Methods & Principles in Medicinal Chemistry
    Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largestpharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone ... Read more

    $150.00 USD

  • Drug Metabolism Prediction

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series Book 63 - Methods & Principles in Medicinal Chemistry
    The first professional reference on this highly relevant topic, for drug developers, pharmacologists and toxicologists.The authors provide more than a systematic overview of computational tools and knowledge bases for drug metabolism research and their underlying principles. They aim to convey their expert knowledge distilled from many years of experience in the field. In addition to the ... Read more

    $148.00 USD

  • Antiviral Drug Strategies

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series Book 50 - Methods & Principles in Medicinal Chemistry
    By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses.It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, ... Read more

    $155.00 USD

  • Natural Products in Medicinal Chemistry

    by Hugo Kubinyi, Gerd Folkers, Raimund Mannhold ...
    Series Book 60 - Methods & Principles in Medicinal Chemistry
    The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters.Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new ... Read more

    $146.00 USD

  • Microwaves in Organic and Medicinal Chemistry

    by C. Oliver Kappe, Alexander Stadler, Doris Dallinger, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series Book 52 - Methods & Principles in Medicinal Chemistry
    Tailored to the needs of medicinal and natural products chemists, the second edition of this unique handbook brings the contents up to speed,almost doubling the amount of chemical information with an additional volume.As in the predecessor, a short introductory section covers the theoretical background and evaluates currently available instrumentation andequipment. The main part of the book then ... Read more

    $170.00 USD

  • Scaffold Hopping in Medicinal Chemistry

    by Raimund Mannhold, Hugo Kubinyi, Gerd Folkers ...
    Series Book 58 - Methods & Principles in Medicinal Chemistry
    This first systematic treatment of the concept and practice of scaffold hopping shows the tricks of the trade and provides invaluable guidance for the reader's own projects.The first section serves as an introduction to the topic by describing the concept of scaffolds, their discovery, diversity and representation, and their importance for finding new chemical entities. The following part ... Read more

    $126.00 USD